Our comparison of mutated genes between tumors from AA and CA cases identified RYR1, RPL10, PTCHD3, BCL7A, SPEF2, MYH13, ABI3BP, BRWD3, GRM7, AUTS2, PARP4, PLD1, ANKRD26, DDX17 and STXBP4 as genes with significantly higher mutation frequencies in AA MM cases (Fig 3, S4 Table). This evidence concerns the gene SPEF2 and Miyoshi myopathy.