S100A8 and atherosclerosis: Bioinformatics analysis of the expression levels of the 92 genes significantly downregulated (fold change<-1.5, P-value<0.05) by miR-195 in THP-1 macrophages revealed that atherosclerosis signaling (P-value = 0.0147) is one of the top canonical pathways, as a result of F3, S100A8 and ALOX5 downregulation (fold change: -1.93, -6.87 and -1.65, respectively), three genes known to be involved in important mechanisms that contribute to disease pathophysiology (Fig 5A) [30,31].