CORE is a Phase II clinical trial for newly diagnosed GBM that recruited 265 GBM patients with the unmethylated MGMT gene promoter and incorporated a two-times weekly or an intense, five-times weekly 2000 milligram cilengitide regimen in combination with conventional treatment (temozolomide with concomitant radiation therapy, followed by temozolomide maintenance therapy) for comparison to conventional treatment alone. The gene discussed is MGMT; the disease is glioblastoma.