MTOR and glioblastoma: To date, there is an ongoing phase II clinical trial with this agent in patients with first or second GBM recurrence (clinical trial #NCT01339052) that is being coordinated by the Dana-Farber/Brigham and Women’s Cancer Center, U.S.A. Beyond single agent inhibitors, the dual inhibition of both the PI3K and mTOR pathway is considered a more effective therapeutic strategy, the most extensively studied being BEZ235 (Novartis), a dual PI3K/mTORC1/2 inhibitor [63].