Interaction of integrin β3 with EGFRvIII stimulated the activation of an integrin β3/SRC/FAK/EGFRvIII signaling axis that led to the activation of ERK1/2 (MAPK), AKT, and STAT3 signaling pathways in the GBM cells and the up-regulation of the cancer cell invasion markers, matrix metalloproteinase-2 (MMP-2) and MMP-9, as well as integrin β3, subsequently promoting GBM cell invasion [85]. Here, PTK2 is linked to cancer.