Several factors that play a crucial role in clear cell RCC, such as hypoxia-inducible factor 1-α inhibitor (HIF1AN), Egl nine homolog 3 (EGLN3), VEGF-A, phosphatidylinositol-3-kinase (PI3K), phosphatase and tensin homolog, and mitogen-activated protein kinase kinase kinase 1 (MAP3K1), might be potential targets of miR-17-5p. The gene discussed is EGLN3; the disease is renal cell carcinoma.