F2RL1 and hepatocellular carcinoma: Although in skin tumorigenesis PAR2 has been suggested to be a tumor suppressor [18], this member of the PAR family has mostly been associated with cancer development and progression because of its ability to control tumor growth, invasion and metastasis in various tumor entities including hepatocellular carcinoma (HCC) and PDAC [6,7,8,9,10,11,12,13].