Despite marked differences in their pathological features—PDAC are stromal-predominant, fibrotic/desmoplastic, poorly vascularized tumors, whereas HCC are cellular and highly vascularized—PDAC and HCC share the G protein-coupled receptor “proteinase-activated receptor 2” (PAR2) and transforming growth factor-β (TGF-β) as key factors involved in primary tumor growth and cancer cell invasion and metastasis. The gene discussed is TGFB1; the disease is cancer.