BCL2 and cancer: ANRIL is dysregulated in several cancers, including BC; in bladder, it regulates cell proliferation and apoptosis through the intrinsic pathway, since its knockdown corresponds to decreased expression of BCL-2, increased expressions of BAX (BCL2 Associated X), cytoplasmic cytochrome c and SMAC (second mitochondria-derived activator of caspases), and cleavage of Caspase-9, Caspase-3 and PARP (poly ADP ribose polymerase) [132].