In BC patient samples, the tumor invasiveness is driven by the TGFβ1 signaling pathway that promotes the EMT through cancer-associated fibroblasts (a major component of the cancer stroma); in this system, TGFβ1 is overexpressed in the presence of an upregulated ZEB2-AS1 (together with ZEB2) [156]. This evidence concerns the gene ZEB2 and breast cancer.