In a recent study including 293 BCC tumors, the driver pivotal role of PTCH1, TP53, and SMO has been confirmed; however, 85% of BCC also harbored additional driver mutations in other cancer-related genes, such as MYCN, PPP6C, PTPN14, STK19, and LATS1 [22]. This evidence concerns the gene SMO and skin basal cell carcinoma.