Other candidate cancer genes were found to be frequently mutated in BCC (Table 1), including ARID1A, CASP8, CSMD1, GRIN2A, KRAS, NOTCH1, NOTCH2, NRAS, PIK3CA, PREX2, and RAC1, although they did not show a statistically significant association with BCC [19,22]. Here, NOTCH1 is linked to skin basal cell carcinoma.