AKT1 and cancer: These include geldana-mycin, which suppresses mTOR phosphorylation of downstream protein regulators [115], phloretin, a common flavonoid capable of inducing cell cycle arrest and apoptosis in part via suppression of AKT/PI3K/mTOR cascades [187], and isoliquiritigenin, another flavonoid that induces autophagic and apoptotic cell death in cancer cells via mTOR signaling [188].