It inhibits cell proliferation via inhibition of cyclin D1 expression, as well as inhibition of NF-kappa B, which is thought to occur via interference with the ubiquitin-mediated proteasome pathway [142], as suggested by increased levels of polyubiquitinated proteins in cancer cells following treatment with withaferin A. It has also been found to selectively induce cell death in multiple types of tumor cells [143,144]. The gene discussed is CCND1; the disease is cancer.