TNF and age-related macular degeneration: Supporting these hypotheses are the facts that both increased CD56 expression on T-cells and CD8+ memory-to-naïve T-cell ratio have been linked to accelerated aging [31–33,36,38,39], as well as obser-vational studies in patients with AMD and experimental studies in mice of laser-induced CNV, where data suggest significant contribution of systemic and local concentrations of IFN-γ, IL-8, IL-13, MCP-1, MIP-1β, and TNF-α [55].