This might be of special interest since specific isoforms dynamically control excitability (e.g. Kv2.1; Misonou et al., 2005) and alter their expression under pathological conditions such as epilepsy (e.g. Kv1.1; Kirchheim et al., 2013; or Kir2.1 and HCN; Stegen et al., 2012) or oxidative stress (e.g. Kv4; Rüschenschmidt et al., 2006). This evidence concerns the gene KCNB1 and epilepsy.