In previous Japanese and Korean studies [4, 6, 13], a particular subset of ICASO mainly diagnosed as atherosclerosis, associated with RNF213 p.R4810K variant (odds ratios, 16.8 and 22.3; 95% confidence intervals, 3.81–74.5 and 3.0–164.1; both p < 0.0001 for Japanese and Korean, respectively). This evidence concerns the gene RNF213 and atherosclerosis.