Self‐reactive IgG and IgE antibodies are commonly detected in both allergic and autoimmune diseases and contribute to the pathogenesis of atopic dermatitis, RA, systemic lupus erythematosus, Hashimoto's thyroiditis, Graves’ disease, BP and MS, and their animal models 74, 75, 76, 77. Here, IGHE is linked to autoimmune disease.