So, in human allergy, while it is probably true that the cytokine microenvironment of the lymph node predominantly affects the activation and shaping of the adaptive immune system, there are influences, including the innate immune system 52 and the degranulation of mast cells and basophils and the activation of eosinophils, that induce an atopic autocrine cycle of cytokine and antibody polarization, leading to higher level of Th2 cells and higher levels of IgE in atopic individuals 53. Here, IGHE is linked to allergic disease.