In our Lifelines sample, five out of 52 included CpGs showed significant associations with type 2 diabetes (the Bonferroni-adjusted p < 0.0009 (0.05/52 CpGs)), including the loci in the ABCG1, LOXL2, TXNIP, SLC1A5 and SREBF1 genes (see a short description in ESM Box 1). This evidence concerns the gene LOXL2 and type 2 diabetes mellitus.