SIRT1 participates in apoptosis [18], autophagy [19], and development [20], as well as in metabolism [21, 22] and circadian rhythms [23, 24]; therefore, it is not surprising that SIRT1 affects more complex biological processes including aging [24–27], MCI [28], and cognitive decline [29–31]. This evidence concerns the gene SIRT1 and Mental deterioration.