SIRT1 and Alzheimer disease: Additionally, in the hippocampus and cortex of SAMP8 mice [71] and in the hippocampus of 3xTg-AD mice [72], SIRT1 upregulated a disintegrin and metalloprotease 10 (ADAM10) [73] and downregulated the phosphorylated form of glycogen synthesis kinase 3 beta (GSK3β) [55, 70] in order to reduce the production of amyloid beta (Aβ) peptides and tau phosphorylation, which have been widely accepted as vital causes of cognitive decline [74].