The majority of epithelial tumors upregulate tissue factor (TF) (1) and tumor-derived extracellular vesicles (EVs), including exosomes (30–150 nm) and membrane-derived microparticles (150–1,000 nm), expressing TF antigen and procoagulant activity have been isolated from plasma of cancer patients (2–4) and conditioned media from cell lines (5–7). Here, TF is linked to neoplasm.