We investigated E-selectin expression and IL-8 secretion in endothelial cells in response to tumor-derived EV, but other proteins and chemokines that may impact metastasis, such as intracellular adhesion molecule-1 (42) and monocyte chemoattractant protein-1 (43), may be upregulated by tumor-derived EV as well. The gene discussed is CCL2; the disease is neoplasm.