TF and cancer: The majority of epithelial tumors upregulate tissue factor (TF) (1) and tumor-derived extracellular vesicles (EVs), including exosomes (30–150 nm) and membrane-derived microparticles (150–1,000 nm), expressing TF antigen and procoagulant activity have been isolated from plasma of cancer patients (2–4) and conditioned media from cell lines (5–7).