Besides, CD147 enhanced tumor growth of melanoma by up-regulating GLUT-1 level via activating PI3K/Akt signaling and increasing glucose uptake, stimulated hepatoma cells escaping from immune surveillance of T cells by interaction with Cyclophilin A, reprogrammed fatty acid metabolism in HCC cells through Akt/mTOR/SREBP1c and p38/PPARα pathways, promoted autophagy through PI3K/Akt/mTOR pathway in human prostate cancer cells, and chemosensitivity in head and neck squamous carcinoma cells by activating MAPK/ERK pathway [48–52]. Here, PPIA is linked to Familial prostate cancer.