Various evidences showed that CD147 might enhance the migration and metastasis of cancer via Annexin A2/DOCK3-β-catenin- WAVE2, EGFR-src-Rac1-pSTAT3-DOCK8, integrin-FAK-PI3K/PIP3-Rac1-WAVE2 and FAK- PI3K/PIP3-Rac1-WAVE2 pathways [43–46]. Here, RAC1 is linked to cancer.