Our meta-analysis combined the results from 15 individual studies with 1,682 NSCLC patients and found that MUC1 overexpression had significantly prognostic value for OS (HR = 2.12, 95% CI: 1.47–3.05; P < 0.001) and PFS (HR = 2.00, 95% CI: 1.53–2.62, P < 0.001) in NSCLC patients. Here, MUC1 is linked to non-small cell lung carcinoma.