OCLN and malignant colon neoplasm: In previous work, ICG uptake was higher in the human colon cancer cell line DLD-1, characterized by the altered immunolocalization of occludin in the lateral wall and apical border of the cells but with normal immunoreactivity of ZO-1 at the apical cell border [42], than by T84 cells [18], in which occludin and ZO-1 are expressed normally.