Also, combined miRNAs with serum protein markers, such as cytokeratin 19 fragment (CYFRA21-1), carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), cancer-associated antigen (CA) 125 and CA 19-9 maybe more effective in the diagnosis of lung cancer [58, 81]. The gene discussed is ENO2; the disease is lung cancer.