GZMB and neoplasm: Pronounced differences were observed for CXCL9, which highly significantly up-regulated in all tumor stages (p<0.0001, all tumors vs. normal tissue), followed by CXCL11 (p<0.0001, all tumors vs. normal tissue) and Granzyme B (p<0.0003, all tumors vs. normal tissue), whereas CXCL10 showed significant upregulation in stage II, but a modest increase upon comparison of all tumor stages to normal colon (p=0.095).