However, despite its presumed role in genomic and epigenomic instability, the involvement of TDG in cancer, and in particular in CRC, is poorly characterized, with the exception of a study in which TDG inactivation in a rectal carcinoma from a patient with constitutional MMR deficiency increased the number of C>T transitions at CpG sites [28]. This evidence concerns the gene TDG and colorectal carcinoma.