In addition, the solid, undifferentiated architecture and nuclear/nucleolar morphology is reminiscent of the histology of human CRC with the so-called CpG island methylator phenotype (CIMP) (37, 102), which raises the possibility that loss of TDG demethylating activities may promote the onset of tumors characterized by altered methylation. The gene discussed is TDG; the disease is colorectal carcinoma.