To evaluate whether Tdg deletion alters the mechanism of inactivation of the second (normal) copy of the Apc gene in adenomas, a total of 4 matched normal colonic mucosa and adenoma samples from Fabpl::Cre+/oTdgflox/-ApcMin/+ mice were analyzed for Apc loss of heterozygosity by pyrosequencing around the ApcMin mutation. The gene discussed is APC; the disease is adenoma.