Importantly, a similar increased number of adenomas (in comparison to the average number of adenomas in control mice not undergoing ovariectomy, Table 1) was detected in both the test Fabpl::Cre+/oTdgflox/-ApcMin/+ genotype group and the control genotype groups (Table 2), indicating that ovariectomy is, in a way, “epistatic” with the mutant Tdg genotype, i.e. the protective effect of female hormones on intestinal tumor formation may be largely TDG-dependent. Here, TDG is linked to adenoma.