IMD-4482 significantly inhibited the adhesion of PAI-1 positive ovarian cancer cells (SKOV3ip1, HeyA8) on VN (10 mmol/L: SKOV3ip1, 74%; HeyA8, 56%, respectively) in a dose-dependent manner, while the adhesion of OVCAR3 cells (PAI-1 negative) was not inhibited by IMD-4482 (Figure 3A and 3B). This evidence concerns the gene SERPINE1 and ovarian cancer.