When administered to not only PAI-1-positive Lewis lung carcinoma but also to PAI-1-negative B16 melanoma tumor-bearing mice, SK-216, a specific PAI-1 inhibitor, caused a significant reduction in subcutaneous primary tumor size and inhibited angiogenesis and metastases, suggesting the involvement of host PAI-1 during tumor progression [37]. Here, SERPINE1 is linked to melanoma.