The present study might provide a step toward understanding the role of PAI-1 in mediating cell adhesion and cell signaling, indicating that a small-molecule PAI-1 inhibitor such as IMD-4482 could become a potential therapeutic agent for ovarian cancer, given that approximately two thirds of ovarian cancers show high PAI-1 expression associated with poor prognosis. This evidence concerns the gene SERPINE1 and ovarian carcinoma.