IMD-4482 induced the cleavage of poly (ADP-ribose) polymerase (PARP) in PAI-1-positive ovarian cancer cells (SKOV3ip1 and HeyA8) but not in PAI-1-negative cells (OVCAR3), indicating that the drug induced apoptosis through PAI-1 inhibition. The gene discussed is SERPINE1; the disease is ovarian cancer.