As large-artery atherosclerotic (LAA) stroke and small-vessel disease (SVD)-related stroke are the most pervasive subtypes in the Chinese Han population [21], and increasing evidence has revealed that the genetic risks vary depending on the subtypes of ischemic stroke [22], it is important to determine whether the variants in or near FOXF2 are associated with the increased risk of ischemic stroke and its subtypes. The gene discussed is FOXF2; the disease is ischemic stroke.