FOXF2 and Stroke: Patients with segmental deletions of this gene showed the extensive, confluent appearance of white matter hyperintensities, and animal experiments showed that conditional FOXF2 mutations induced the development of cerebral infarction, microhemorrhage, and defects in the differentiation of cerebral vascular mural cells [20, 25]; Recently, a common variant, rs12204590 near FOXF2, was found to be associated with increased susceptibility to stroke.