SYNJ2 and neoplasm: PI(3,4,5)P3 can be dephosphorylated by Synaptojanin 2 (SH2-containing inositol polyphosphate 5-phosphatase, SYNJ2) to yield PI(3,4)P2, and SYNJ2 recruits TKS5 and forms new invadopodia resulting in increasing tumor invasiveness [10].