We preliminarily found that DHX15 participates in the regulation of leukemia cell apoptosis through the NF-kB-BCL-2/BCL-XL-CASP3/PARP pathway; however, further studies are required to clarify whether abnormal RNA helicase activity or splicing is the mechanism underlying the multiple functions of DHX15. The gene discussed is DHX15; the disease is leukemia.