RNA helicase DHX29 is overexpressed in various types of cancers,[2] and the down-regulation of DHX29 leads to impaired translation and suppression of cancer cell growth ex vivo and in vivo.[2] DDX5 is highly expressed in primary human T-ALL leukemia cells.[3] Knockdown of DDX5 results in reduced cell proliferation and increased apoptosis in cultured human leukemia cells and suppression of growth of human leukemia xenografts in nude mice.[3]. The gene discussed is DDX5; the disease is acute lymphoblastic leukemia.