Univariate Cox regression analysis with all Rennes patients (GSE22891 [15] and Rennes cohort collectively) shows that age, glioma-CpGs island methylator phenotype (G-CIMP) status, TCGA gene expression subtypes, MGMT methylation status, and the hypomethylation signature are all significantly correlated with OS (Table 1). Here, MGMT is linked to central nervous system cancer.