The main new findings here are i) higher expression of cFLIP in thymomas and TSCCs compared to NT in vivo; ii) delayed decline of cFLIP levels and delayed senescence in cultured neoplastic pTECs compared to normal pTECs; iii) regulation of cFLIP expression through NF-κB signaling in neoplastic pTECs; and iv) cell death induction through autophagy and apoptosis by cFLIP knockdown and NF-κB inhibition in pTECs. The gene discussed is NFKB1; the disease is thymoma.