This revealed that a number of HOX genes were significantly related to survival in AML, including HOXA5 (p = 0.03), HOXB2 (p = 0.002), HOXB4 (p = 0.037), HOXB9 (p = 0.001), and HOXC9 (p = 0.007) (Figure 1), whilst HOXA4 (p = 0.067) and HOXA9 (p = 0.06) showed borderline significance. The gene discussed is HOXB4; the disease is acute myeloid leukemia.