The tumor-supportive microenvironment of PDAC is created by activation of PSCs by PCCs, and the most potent stimulants for PSCs are platelet-derived growth factor (PDGF), fibroblast growth factor (FGF), and transforming growth factor-β1 (TGF-β1) [8, 34]. The gene discussed is TGFB1; the disease is neoplasm.