In AßPP/PS1 (presenilin 1) double mutant transgenic mouse model of Alzheimer's disease, EGCG restored mitochondrial respiratory rates, mitochondrial membrane potential (MMP), reactive oxygen species (ROS) and ATP levels in several brain regions including hippocampus, cortex, and striatum [20]. The gene discussed is PSEN1; the disease is early-onset autosomal dominant Alzheimer disease.