The tumor suppressor activity of PTEN is a lipid phosphatase [38], it dephosphorylating the lipid second messenger phosphatidylinositol 3,4,5- trisphosphate thus antagonizing the phosphoinositide 3-kinase-Akt pathway and preventing activating phosphorylation of Akt [39–44]. Here, AKT1 is linked to neoplasm.