Critically, we found that in homozygous CD19cre mice, lupus-inducing pristane did not reduce thymic immature CD4-CD8+CD3loRORγt+T cells and up-regulated mature CD4-CD8+CD3+RORγt+T cells (Figure 5A and 5B). The gene discussed is CD8A; the disease is systemic lupus erythematosus.