As expected, we found that IgG from C57BL/6, non-lupus-prone and lupus-prone mice reduced thymic immature CD4-CD8+CD3loRORγt+T cells and up-regulated mature CD4-CD8+CD3+RORγt+T cells (Supplementary Figure S6, Figure 7D and 7E). The gene discussed is CD8A; the disease is systemic lupus erythematosus.