In accordance with these results, we found that B-cell reduction with TACI-IgG reduced mature thymic CD4-CD8+CD3+RORγt+T cells and up-regulated immature thymic CD4-CD8+CD3loRORγt+T cells in lupus-prone MRL/lpr mice (Supplementary Figure S2F and S2G). The gene discussed is CD8A; the disease is systemic lupus erythematosus.