To further prove the effect of thymic B cells on the differentiation of thymic immature CD4-CD8+CD3loRORγt+T cells into mature CD4-CD8+CD3+RORγt+T cells, we transferred thymic B cells from non-lupus-prone and lupus-prone mice into non-lupus-prone mice. The gene discussed is CD8A; the disease is systemic lupus erythematosus.