CD4 and systemic lupus erythematosus: In accordance with this study, we found that thymic CD4+CD8- and CD4-CD8+T cell percentage and absolute numbers increased in lupus-prone mice (Figure 1D-1F, Figure 2D, 2E, Supplementary Figure S2D and S2E) with a significant increase in CD8+ ISP cells (Figure 4C-4E, Figure 5A, 5B, Supplementary Figure S2F, S2G).