Importantly, CD4-CD8+CD3loRORγt+ T cells were induced from a novel population of thymic immature T cells (CD4-CD8+CD3loRORγt+) by IgG secreted by B cells from lupus-prone mice (Figure 4-7, Supplementary Figure S2, S5 and S6). This evidence concerns the gene CD4 and systemic lupus erythematosus.