To assess the effect of thymic B cells on the transformation of thymic immature CD4-CD8+CD3loRORγt+T cells into mature CD4-CD8+CD3+RORγt+T cells in autoimmune diseases, we injected lupus-inducing pristane into homozygous CD19cre mice. The gene discussed is CD8A; the disease is systemic lupus erythematosus.