Previous studies have primarily focused on the involvement of HTRA1 in cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (9), age-related macular degeneration (10), malignancy (11), pregnancy-induced hypertension (12), and other diseases; however, the relationship between HTRA1 and inflammatory diseases is unknown. This evidence concerns the gene HTRA1 and Leukoencephalopathy.