On day 7 after infection, although there was no difference in the total number of CD8+ T cells in the spleen of mice that received either OT-I or OT-I CD40L−/−CD8+ T cells (Figure 4B), only about 15% of the number of OVA-specific CD8+ T cells were found in mice that received OT-I CD40L−/−CD8+ T cells (Figure 4C), consistent with data from the previous experiment. Here, CD8A is linked to infection.