KLRK1 and neoplasm: Extrapolating our findings to the human situation, one may predict that persistent engagement and downregulation of NKG2D in the tumor microenvironment may also affect the functionality of other activating receptors sharing signaling adaptors with NKG2D on cytotoxic lymphocytes, and, possibly, given the observed slight impairment of NK1.1 expression and function, even functionality of activating receptors using other adaptors such as FcRγ.