MAPT and Alzheimer disease: More recently, Dunn et al. demonstrated in triple transgenic AD (3xTg-AD) mice, a transgenic mouse strain that expresses the Aβ-processing related mutations APPSWE and PS1M146V as well as mutant, pro-aggregant tau (tauP301L), thus respectively developing accelerated senile plaque and neurofibrillary tangle pathology, that brain LXA4 levels significantly decreased with age.