TGF-β1 was also shown to decrease the expression of the activating receptors, natural killer protein 30 (NKp30), natural killer group 2D (NKG2D), and DNAX accessory molecule-1 (DNAM-1), leading to reduced synthesis and release of IFN-γ, as well as granule exocytosis, resulting in attenuation of tumor killing (34). The gene discussed is CD226; the disease is neoplasm.