Among them, myeloid-derived suppressor cells (MDSCs) have been found to be expanded in MM (73, 74) and to directly contribute to downregulation of NK cell responsiveness via the NKp30-activating receptor (75), membrane-bound TGF-β (76), and TIGIT-mediated inhibitory signaling (77). This evidence concerns the gene TGFB1 and Miyoshi myopathy.