FCGR3A and Miyoshi myopathy: ADCC to CD38+ MM cellsCytolytic activity to MM cells triggered by CD16 signaling upon recognition of antibody tagged to CD38 antigen. NK cell-mediated cytotoxicity induced by DARA could be enhanced by lenalidomide and KIR blockade.Other mechanisms: complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and apoptosis (Figure 2B)