The Leu-rich epitopes have also been shown to induce an IL-17 response in different autoimmune diseases such as NLRP3 (autoimmune encephalomyelitis) (45), FLRT2 (systemic lupus erythematosus) (46, 47), and LGI1 (limbic encephalitis) (48–50). This evidence concerns the gene NLRP3 and autoimmune disease.