The Leu-rich epitopes have also been shown to induce an IL-17 response in different autoimmune diseases such as NLRP3 (autoimmune encephalomyelitis) (45), FLRT2 (systemic lupus erythematosus) (46, 47), and LGI1 (limbic encephalitis) (48–50). Here, NLRP3 is linked to systemic lupus erythematosus.