In conclusion, this study provided the first demonstration that NK cells can protect against alcohol-induced fatty liver through IFN, which directly downregulates lipogenesis in hepatocytes, and alcohol consumption also induces a regulatory NKT10 subset of hepatic iNKT cells to release high levels of IL-10 which subsequently inhibits recruitment and functions of NK cells, to antagonize the protective effects of NK cells. Here, IFNA1 is linked to Hepatic steatosis.