Our observation that PD-1hiICOSint and PD-1intICOShi CD4+ TIL are linearly correlated in 90% of BC, suggests that effector Th plus TfhX13 TIL frequently expand in parallel with activated Treg TIL (10), thereby generating anti-tumor immunity and memory that is regulated by immune feedback mechanisms. Here, CD4 is linked to neoplasm.