As a categorical variable, PD-L1+ TIL (defined as >1% PD-L1+ cells in any TIL subset) were associated with tumor size, in the presence of an iCTLA-4hiCD4+ TIL subpopulation and PD-L2+ TIL (defined as >1% PD-L2+ cells in any TIL subset) (Table S7B in Supplementary Material). The gene discussed is CD274; the disease is neoplasm.