Immunotherapy strategy based on intentional activation of Vγ9Vδ2 T cells in vivo by administration of PAgs or n-BPs and IL-2 has been effective in activating circulating Vγ9Vδ2 T cells, but there is no evidence that this approach reaches tissue-resident γδ T cells or even promotes their recruitment at the tumor site, where they should in fact exert their antitumor activities. Here, IL2 is linked to neoplasm.