IL2 and neuroblastoma: Finally, a recent prospective, non-randomized Phase I trial, has been conducted in nine young patients with refractory neuroblastoma, which has demonstrated that in vivo administration of Zoledronate and IL-2 s.c. can safely expand in vivo circulating Vγ9Vδ2 T cells, suggesting that intentional in vivo activation of Vγ9Vδ2 T cells might represent a strategy for the treatment of neuroblastoma (65).