MaR1 also possess potent anti-nociceptive actions, dose dependently inhibiting transient receptor potential cation channel subfamily V member 1 (TRPV1) currents in neurons, blocking capsaicin (CAP, 100 nM)-induced inward currents (IC50 = 0.49 ± 0.02) and reducing both inflammatory and chemotherapy-induced neuropathic pain in mice (11, 59, 60). This evidence concerns the gene TRPV1 and neuropathic pain.