Interestingly, Sasaki et al. (56) showed that the prophylactic or therapeutic treatment of IL-10−/− mice with anti-inflammatory 18β-glycyrrhetinic acid (GA) can completely inhibit P. gingivalis-induced alveolar bone loss in mice, indicating that the anti-inflammatory mode of action of IL-10 is needed to prevent periodontitis. Here, IL10 is linked to periodontitis.