On the other hand, Bogers and colleagues used an immunization approach to target both virus and CCR5 (three extracellular peptides of CCR5, an N-terminal HIV gp120 fragment generated in transgenic plants and recombinant SIV p27) (117); this strategy of vaccination showed a significant block of the virus infection by eliciting good serum and vaginal quantity of Abs (117). Here, ITIH4 is linked to viral infectious disease.