It is relevant underline that natural anti-CCR5 Abs reproduce a protective status similar to that one observed for Δ32 mutation, although an approach based on CCR5 vaccine in individuals who can contract HIV infection may be a more possible and safe goal compared to gene therapy, taking into account the HIV epidemiology and the trouble of implementing CCR5 gene therapy in people living in developing countries. Here, CCR5 is linked to HIV infectious disease.