No or reduced TACI membrane expressionImpaired NF-κB signalingImpaired IgA and IgG class switchingReduced response to TI-2 AgsB-cell lymphoproliferations, splenomegalyIncreased frequency of autoimmune diseasesLack of lupus-like symptoms. The gene discussed is TNFRSF13B; the disease is Autoimmunity.