NLRP3 and ischemia: Having hypothesized that the NLRP3 inflammasome would be required for the generation of sterile inflammation following lung IR, we subjected ASC KO and NLRP3 KO mice that lack either all inflammasome subtypes or just NLRP3 inflammasomes, respectively, to 1 h of ischemia followed by 1 h of reperfusion.