NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is widely recognized as having a central role in various sterile inflammatory processes and conditions, including trauma/hemorrhage, gout, tissue necrosis, Alzheimer’s, atherosclerosis, and renal IR (4, 14, 27, 51–53). The gene discussed is NLRP3; the disease is atherosclerosis.