IAV infection exposes the host cell to single-stranded genomic RNA and double-stranded RNA intermediates of viral replication, which are recognized by endosomal toll-like receptor (TLR) 3 or TLR7 (Rehwinkel et al., 2010) and the cytoplasmic RNA helicase retinoic acid inducible gene I (RIG-I) (Pichlmair et al., 2006); such recognition drives the activation of antiviral responses during viral infection. This evidence concerns the gene RIGI and viral infectious disease.