The high frequency of the TMPRSS2-ERG gene fusion in PCa is not due to random translocations but is promoted by the androgen receptor inducing changes in chromosomal architecture leading to the proximity of the TMPRSS2 and ERG genes that are then fused following double-strand breaks (DSB) and repair via the non-homologous end joining (NHEJ) pathway (25). This evidence concerns the gene TMPRSS2 and posterior cortical atrophy.