In the current meta-analysis, a significant association was detected between SUMO4 gene M55V polymorphism and T2DM under the allelic (OR: 1.18), recessive (OR: 1.59), dominant (OR: 0.815), homozygous (OR: 1.415), heterozygous (OR: 1.191), and additive (OR: 1.184) genetic models. Here, SUMO4 is linked to type 2 diabetes mellitus.