Schnidar et al. (59) reported that the HH/GLI pathway cooperates with the epidermal growth factor receptor (EGFR) pathway to synergistically induce oncogenic transformation; and that pharmacologic inhibition of both EGFR and HH-Gli effectively reduces the growth of basal cell carcinoma (BCC) cell lines derived from mice with activated HH/GLI signaling. The gene discussed is GLI1; the disease is basal cell carcinoma.